Nuclear apocalypse, following survivors rebuilding Hope County, Montana, who are terrorized by the ruthless, motorcycle-riding Highwaymen, led by the villainous twin sisters Mickey and Lou.
William "B.J." Blazkowicz fighting the Nazis, initially thwarting their supernatural plans in WWII, but later in an alternate 1960s where the Nazis won using advanced tech.
Kassandra visit Greece, as she seek to reunite her fragmented family, dismantle the shadowy Cult of Kosmos manipulating the war, and uncover Isu (First Civilization) secrets, all while wielding a powerful Isu spear and confronting her own destiny.
Isaac Clarke and the crew of the repair vessel Kellion, assigned to the USG Ishimura, a massive planetary mining ship operated by the Concordance Extraction Corporation (CEC) that has gone silent above the planet Aegis VII.
Amicia and Hugo de Rune who must look for a cure to Hugo's blood disease in Southern France while fleeing from soldiers of the Inquisition and hordes of rats that are spreading the black plague.